Evasionofhostimmuneresponses is well documented for viruses and may also occur during tumor immunosurveillance.
1
This finding led us to hypothesize that a conserved structural basis of antigenicescape from anti-AMA-1 exists.
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Here, we describe the evolution of antigenicescape variants in a rhesus macaque that developed unusually high neutralizing antibody titers to SIVmac239.
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By using an in vitro model of antigenicescape, the inhibitory contribution of 24 polymorphic sites of the 3D7 AMA-1 vaccine was determined.
1
This is particularly true for HIV, which has developed numerous immuneevasion mechanisms.
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For example, tumor cells have been shown to develop active immuneevasion mechanisms.
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Therefore, viruses have developed mechanisms to target TRIMs for immuneevasion.
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Exhaustion and suppression of antiviral immune responses can result in viral immuneevasion.
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This immuneevasion mechanism imposes limitations on antibody-based vaccination and convalescent serum therapy.
Uso de immune escape en inglés
1
Tumor immuneescape has been a major problem for developing effective immunotherapy.
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Augmenting immune surveillance and suppressing immuneescape are crucial in tumor immunotherapy.
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Recent evidence has revealed that oncogenic mutations may confer immuneescape.
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The HPV protein responsible for inducing this immuneescape has not been determined.
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Secondly, graft failure and the immuneescape of extramedullary plasmocytoma have been reported.
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These findings suggest a strategy for overcoming cancer therapy resistance and immuneescape.
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We speculate that such immune complexes might facilitate immuneescape of cancer cells.
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The failure of the system results in immuneescape and proceeds to tumor growth.
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This massive stroma drives the immuneescape in the tumour.
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Resisting cell death, reprogrammed metabolism and immuneescape are fundamental traits of hard-to-treat cancers.
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The data describe a novel immuneescape mechanism and better define suitable target epitopes for ATT.
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We conclude that the aberrant expression of HLA-G may contribute to immuneescape in human glioblastoma.
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The constrained mutations occurred at sites enriched in T-cell epitopes, suggesting they promote viral immuneescape.
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Conclusions: These results support the concept that there is a host- immuneescape associated with bladder cancer.
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Loss of tumor cell human leukocyte antigen (HLA) is an immuneescape mechanism for malignancies.
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This is significant for understanding the biological behavior of DCs and the immuneescape mechanism of tumors.